邸金鑫,朱艳华

原发性痛经（primary dysmenorrhea，PD）是青春期最常见的妇科病，也是女性盆腔疼痛最常见的原因之一，是临床上妇科医生面临的多发疾病，对女性的生活质量产生负面影响并干扰日常活动，且原发性痛经发病机制复杂。NF-KB作为炎症反应中重要的转录因子，被激活后可介导炎症因子的转录，能够诱发PD发病或是加重病情。现代科学研究亦证实，PD的出现往往伴随着NF-κB相关信号通路的特异激活。本文就中药调控NF-KB信号通路及相关通路在PD进程中的作用作一综述，以期为相关研究提供参考。近年来研究表明中药单体（阿魏酸、芍药苷、橙皮苷等）及中药复方（血府逐瘀汤、少腹逐瘀汤、当归芍药散等）都可以通过影响肿瘤坏死因子α（TNF-α）、Toll样受体4（TLR4）、细胞外信号调节激酶（ERK）等信号通路调控核因子-KB（NF-κB）参与PD的发生发展进程，因此通过抑制NF- κB信号通路可能是防治PD的新靶点。

NF- KB信号通路；原发性痛经；中药；综述

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