拉古纳坦·约瑟夫,奥尔森·卢布纳

缺铁性贫血（IDA） 是全世界最普遍和可治疗的贫血形式。 IDA 患者的临床管理需要全面了解可导致缺铁的许多病因，包括妊娠、失血、肾脏疾病、月经大量出血、炎症性肠病、减肥手术或极其罕见的遗传疾病。 IDA 的许多原因的治疗前景目前正转向更大量地使用静脉内 （IV） 铁剂，因为它的有效性和改进的配方减少了不良反应的可能性。 IV 铁剂的应用已超出 IDA 的治疗范围，有关其对心力衰竭、不宁腿综合征、疲劳和预防急性高山病患者疗效的数据越来越多。本综述提供了诊断、管理和治疗 IDA 患者的框架，并讨论了可从补铁中获益的其他情况。

贫血；血液病理学；缺铁；铁充足

[1] Kassebaum NJ, Jasrasaria R, Naghavi M, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123(5):615-624. [2] West AR, Oates PS. Mechanisms of heme iron absorption: current questions and controversies. World J Gastroenterol. 2008;14(26): 4101-4110. [3] Sharp P, Srai SK. Molecular mechanisms involved in intestinal iron absorption. World J Gastroenterol. 2007;13(35):4716-4724. [4] Killip S, Bennett JM, Chambers MD. Iron deficiency anemia. Am Fam Physician. 2007;75(5):671-678. [5] DeLoughery TG. Iron deficiency anemia. Med Clin North Am. 2017;101(2):319-332. [6] Careaga M, Moize V, Flores L, Deulofeu R, Andreu A, Vidal J. Inflammation and iron status in bariatric surgery candidates. Surg Obes Relat Dis. 2015;11(4):906-911. [7] Kumari R, Bharti RK, Singh K, et al. Prevalence of iron deficiency and iron deficiency anaemia in adolescent girls in a tertiary care hospital. J Clin Diagn Res. 2017;11(8):BC04-BC06. [8] Miller JL. Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med. 2013;3(7):a011866. [9] Auerbach M, Deloughery T. Single-dose intravenous iron for iron deficiency: a new paradigm. Hematology Am Soc Hematol Educ Program. 2016;2016(1):57-66. [10] Camaschella C. Iron deficiency: new insights into diagnosis and treatment. Hematology Am Soc Hematol Educ Program. 2015;2015:8-13.

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