Adi Januar Akbar,Willy Yusmawan,Farokah,Nur Iman Nugroho

背景：鼻咽癌（NPC）是一种位于鼻咽部的恶性肿瘤，可以通过顺铂治疗，这种化疗的副作用是增加活性氧（ROS）的产生，从而损害肝脏。我们的目的是确定将皇冠果作为一种抗氧化剂对接受顺铂化疗的鼻咽癌患者的肝功能的影响。研究对象和方法：将40名III期和IV期鼻咽癌患者的受试者分为治疗组和对照组。在顺铂化疗前对受试者进行SGOT SGPT检测。治疗组从化疗前一周开始服用皇冠果胶囊，每24小时300mg，为期5周。对照组在化疗前一周开始每天服用安慰剂胶囊，为期5周。患者接受了两个疗程的顺铂化疗，间隔时间为3周，然后在第二个疗程的顺铂化疗后1周抽取第二次血样。结果：治疗后的皇冠果组和对照组的SGOT水平有显著差异，皇冠果组和对照组的治疗前后差异也很大。此外，在治疗前和治疗后，皇冠果组和对照组的SGPT水平也有显著差异。结论：服用皇冠果对降低接受顺铂化疗的鼻咽癌患者的SGOT和SGPT水平有一定作用。

皇冠果；SGOT；SGPT；鼻咽癌；顺铂

[1] Adham M, Kurniawan AN, Muhtadi AI, Roezin A, Hermani B, Gondhowiardjo S, Tan IB, et al. (2012). Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chin J Cancer. 31(4):185-196. DOI: 10.5732/cjc.011.10328. [2] Alara OR, Alara JA, Olalere OA. (2016). Review on Phaleria macrocarpa Pharmacological and Phytochemical Properties. Drug Des. 5:134. [3] Altaf R, Asmawi MB, Dewa A, Sadikun A, Umar M. (2013). Phytochemistry and medicinal properties of Phaleria macrocarpa (Scheff.) Boerl. extracts. PharmacognRev. 7(1):73. DOI: 10.4103/0973-7847.112853. [4] Asrity A, Tsan FY, Ding P, Aris S. (2018). Functional Properties of Phaleria macrocarpa Fruit Flesh at Different ripeness. Int Food Res J. 25(3):1273–80. [5] Azad A, Chang P, Devuni D, Bichoupan K, Kesar V, Branch AD, Oh WK, et al. (2018). Real World Experience of Drug Induced Liver Injury in Patients Undergoing Chemotherapy. J Clin Gastroenterol Hepatol. 2(3):18. DOI: 10.21767/2575-7733.1000047. [6] Bouché M, Vincent B, Achard T, Bellemin-Laponnaz S. (2020). N-Heterocyclic Carbene Platinum (IV) as Metallodrug Candidates: Synthesis and 195Pt NMR Chemical Shift Trend. Molecules. 25(14): 3148. Doi: 10.3390/molecules25143148. [7] Chu NH, Li L, Zhang X, Gu J, Du YD, Cai C, Xiao HP. (2015). Role of Bicyclol in Preventing Drug-Induced Liver Injury in Tuberculosis Patients with Liver Disease. Int J Tuberc Lung Dis. 19(4):475. DOI: 10/5588/ijtld.14.0579. [8] Farhat, Adham M, Dewi YA, Indrasari SR, editor. (2014). Karsinoma Nasofaring. Penerbit Buku Kedokteran EGC. [9] Hang Z, Cooper MA, Ziora ZM. (2016). Platinum-Based Anticancer Drugs Encapsulated Liposome and Polymeric Micelle Formulation in Clinical Trials. Bio Chem Comp. 4:1–4. DOI: 10.7243/2052-9341-4-2. [10] Komite Penanggulangan Kanker Nasional (2012). Pedoman Nasional Pelayanan Kedokteran Kanker Nasofaring. Kementerian Kesehatan Republik Indonesia. [11] Komite Penanggulangan Kanker Nasional (2017). Panduan Penatalaksanaan Kanker Nasofaring. Kementerian Kesehatan Republik Indonesia. [12] Lala V, Goyal A, Bansal P, Al E. (2020). Liver Function Tests. StatPearls.Treasure Isl StatPearls Publ. [13] Nasution AN, Aziz H, Tjong DH, Zein R. (2019). Effect of Phaleria macrocarpa Flesh Fruits Extract on MDA Level, SGOT and SGPT Activity in Serum of Experimental Rats Contaminated by Cd (II) Ion. Open Access Maced J Med Sci. 7(23):3950–3954. DOI: 10.3889/oamjms.2019.786. [14] Rehman MU, Rather IA. (2019). Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats. Plants (Basel, Switzerland), 9(1), 28. DOI: 10.3390/plants9010028 [15] Santosa YI, Samiadi D, Aroeman NA, Fianza PI (2012). Pengaruh Alfa Tokoferol pada Efek Ototoksik Sisplatin. MKB,:205–12. DOI: 10.15395/mkb.v44n4.176. [16] Simo R, Robinson M, Lei M, Sibtain A, Hickey S. Nasopharyngeal carcinoma: United Kingdom National Multidisciplinary Guidelines. [J] Laryngol Otol. 2016 May;130(S2): S97-S103. DOI: 10.1017/S0022215116000517. [17] Topik A (2014). Oxidatively Modified DNA Lesions and Systems for Reparation. Sources, Clinical Significance and Methods of Analysis. Omi Gr United States Am. 53–5. [18] Widiono KR, Yusmawan W, Naftali Z. (2017). Perbandingan Five Year Survival Rate Penderita Karsinoma Nasofaring pada Modalitas Kemoterapi dan Kemoradiasi. J Kedokt Diponegoro. 6. [19] Wu L, Li C, Pan L. (2018). Nasopharyngeal carcinoma: A review of current updates. Experimental and therapeutic medicine. 15(4): 3687–3692. DOI: 10.3892/etm.2018.5878.

点击下载PDF