张景怡

抑郁症是一种普遍存在的疾病，发病率和死亡率很高。传统的治疗干预措施不针对相关的病理生理学，而且往往副作用大甚至无效。抑郁症患者大脑功能和结构均发生改变，尤其在前额叶皮层。经颅直流电刺激（TDCS）施加低强度的连续电流，改变皮质兴奋性，操纵神经元活动和神经可塑性。运动已被证明可以重塑抑郁症患者的大脑结构，激活相关脑区的功能，促进行为适应改变，维持海马和白质体积的完整性，从而改善抑郁症患者的大脑神经处理和延缓认知退化。本文TDCS和运动两种干预方式的作用机制、临床效果、刺激强度及存在的问题等方面进行综述，旨在为抑郁的治疗及后续深入研究提供参考。

经颅直流电刺激；抑郁；背外侧前额叶皮质；运动干预

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