詹铭瑜

N6-甲基腺嘌呤(N6-methyladenosine, m6A)是高等真核生物中最普遍的RNA甲基化修饰类型。其在包括mRNA、tRNA、长链非编码RNA（lncRNA）的RNA活动中都发挥作用。m6A修饰是由甲基转移酶(writers)、去甲基酶(erasers)和m6A结合蛋白(readers)参与的可逆介导。m6A参与RNA剪接、RNA编辑、翻译等多个阶段。本文围绕m6A甲基化的机制、分布位点、在疾病发生发展中调控的机制及相关研究进展进行综述。

m6A甲基化；m6A-seq；癌症

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