廖科勇,鲁红云

随着经济的快速发展和人民生活方式的提高，非酒精性脂肪肝病已成为临床上最常见的慢性肝病，全球率高达32.4%，超过所有病毒性肝炎的总和。但其发病机制尚未完全明确，随着基因检测技术和高通量测序技术的发展，大量研究发现非编码RNA与非酒精性脂肪肝的发病机制有不可分割的关系。长非编码RNA是一类长度超过200个核苷酸且不能翻译肽的RNA分子，研究发现lncRNA与疾病多个方面密切相关，包括组蛋白修饰、转录、DNA 甲基化和染色质重塑的调控等转录后调控机制，可导致疾病的发生发展。该文综述了近3年来lncRNA在非酒精性脂肪肝中的调控作用，以期为非酒精性脂肪早期筛查、诊断、治疗提供理论依据，以及寻找与非酒精性脂肪肝预后相关的特异标志物。

长链非编码RNA；非酒精性脂肪肝；发病机制

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