戚家铭

为获取重度抑郁症患者的血液样本的基因生物标志物，从GEO数据库中选择GSE52790和GSE76826数据集，筛选共差异表达基因。通过GO和KEGG分析获取富集通路，从GeneCards数据库中获取与核糖体相关基因，进一步得到核糖体相关的共差异表达基因。构建LASSO模型，获得12个基因生物标志物，分别是RPL26、EIF3L、HABP4、MAPK14、SRPK1、BLMH、TMEM109、AIM2、KISS1、IARS2、RHBDD2、ARMC1，用ROC曲线来评估诊断效果。使用药物基因相互作用数据库DGIdb预测与基因生物标志物相关的潜在药物。

重度抑郁症；核糖体相关；LASSO回归；生物标志物

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