郭 砚,三芬娟

脱发是临床上常见的毛发疾病，雄激素性脱发（Androgenic alopecia,AGA）是其中最常见的类型之一。此前，A型肉毒毒素被广泛应用于美容领域，近年来，其在脱发治疗方面也显示出巨大的潜力。本文旨在通过对A型肉毒毒素治疗雄激素性脱发相关文献的梳理和评价，进一步阐明雄激素性脱发的发病机制及A型肉毒毒素治疗雄激素性脱发的机制、临床有效性及安全性。为临床研究人员提供关于A型肉毒毒素治疗雄激素性脱发全面、深入的了解。

A型肉毒毒素；雄激素性脱发；有效性；安全性

[1] A A P ,A C J ,M A C .Hair follicle predetermination.[J].Journal of cell science,2001,114(Pt 19):3419-31. [2] 胡志奇,苗勇.中国人雄激素性脱发诊疗指南[J].中国美容整形外科杂志,2019,30(01):8-12. [3] 李盛,黄茜,陈敏.雄激素性脱发的发病机制与激光治疗[J].激光生物学报,2016,25(02):107-111. [4] English Jr RS, Ruiz S. Use of botulinum toxin for androgenic alopecia: a systematic review. Skin Appendage Disorders. 2022 Mar 8;8(2):93-100. [5] Stefanie H ,K A K ,Nadine F , et al.Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology.[J].The Journal of investigative dermatology,2013,133(6):1489-96. [6] 孙建林,吕新翔.雄激素性脱发的发病机制与治疗进展[J].内蒙古医科大学学报,2020,42(01):106-108+112. [7] 杨堃,付聪,凌佳琦,等.A型肉毒毒素治疗雄激素性脱发的机制及研究进展[J].中国美容整形外科杂志,2022,33(01):23-25. [8] Maher SA,Ismail NA,Toraih EA, et al. Hair Follicle-Related MicroRNA-34a Serum Expression and rs2666433A/G Variant in Patients with Alopecia: A Cross-Sectional Analysis. Biomolecules. 2022;12 (5):. doi:10.3390/biom12050602 [9] 刘琴月.雄激素性脱发患病影响因素分析[D].华北理工大学,2022.DOI:10.27108/d.cnki.ghelu.2022.000890. [10] Castro M F ,Grassi A S ,Rodrigo G , et al.Complications with the use of botulinum toxin type a in facial rejuvenation: report of 8 cases.[J].Aesthetic plastic surgery,2004,28(6):441-4. [11] Zhang T,Cao S,Yuan H, et al. Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway. Pharmaceuticals (Basel). 2021;14 (11):. doi:10.3390/ph14111128 [12] J B F,Marvin S. Treatment of male pattern baldness with botulinum toxin: a pilot study.[J]. Plastic and reconstructive surgery,2010,126(5). [13] 章晾.肉毒毒素注射联合中胚层疗法治疗雄激素性脱发[J].中国医疗美容,2018,8(06):12-14.DOI:10.19593/j.issn.2095-0721.2018.06.004. [14] 崔晶,金珊,南美兰,等.A型肉毒素下调UVB诱导的HaCaT细胞炎症因子的表达[J].中国皮肤性病学杂志,2019,33(10):1121-1124.DOI:10.13735/j.cjdv.1001-7089.201901123. [15] Hussein RS, Dayel SB, Abahussein O. Botulinum Toxin A for Hair Loss Treatment: A Systematic Review of Efficacy, Safety, and Future Directions. JPRAS open. 2023 Sep 21. [16] Wei, W., Zhao, G., Li, Q. et al. Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis. Aesth Plast Surg 48, 1473–1486 (2024). https://doi.org/10.1007/s00266-023-03834-w [17] 周亚光,于水,赵纪敏,赵梓纲.A型肉毒毒素治疗雄激素性脱发的临床研究[J].中国美容医学,2021,30(05):101-103. [18] 王洁,何振兴,赵菊花,李娜.小剂量肉毒毒素注射联合光子治疗在雄激素源性脱发中的应用[J].中国美容医学,2022,31(06):5-8. [19] 徐林刚,陈龙金,李彦锋,弓辰,王阳子,李永林.自体浓缩生长因子联合A型肉毒毒素治疗男性雄激素性脱发临床疗效[J].中国医疗美容,2022,12(07):51-56.

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