姚 艳,魏红艳

反复呼吸道感染(recurrent respiratory tract infections，RRTI)是儿童常见的感染性疾病，尤其近年来发病率明显上升，严重者影响患儿身心健康，甚至导致并发症。人们对维生素D（VD）的研究从未停止，已有研究发现VD缺乏与龋齿、过敏性疾病、克罗恩等似乎都有一定的联系。有研究表明，VD可以通过影响儿童免疫功能在RRTI患儿治疗及预防中发挥作用，本文就其在免疫系统中的作用及与RRTI研究进展展开叙述。

维生素D；儿童反复呼吸道感染；免疫功能

[1] 王宇茹,冀芮,邹静雯,等.维生素D及铁与儿童反复呼吸道感染相关性研究进展[J].中国药业,2023,32(10):127-131. [2] 张慧敏,王玉杰,张慧颖.反复呼吸道感染患儿接受维生素AD滴剂辅助疗法的效果探究[J].现代医学与健康研究电子杂志,2024,8(02):16-18. [3] Lewandowicz-Uszyńska A, Pasternak G, et al. Immunoglobulin G Deficiency in Children with Recurrent Respiratory Infections with and Without History of Allergy. Adv Exp Med Biol. 2021;1289:63-70. [4] Ismailova A, White JH. Vitamin D, infections and immunity. Rev Endocr Metab Disord. 2022 Apr;23(2):265-277. [5] White JH. Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity. Nutrients. 2022 Jan 11;14(2):284 [6] Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010 Mar 19;140(6):805-20. [7] 吴依然,张敏,崔明明,等.维生素D与儿童感染性疾病相关性及其抗感染机制研究[J].中国感染控制杂志,2020,19(11):1037-1041. [8] 莫丽亚,邓永超.维生素D缺乏与儿童感染性疾病.中华检验医学杂志,2015,38(04):226-228. [9] Teymoori-Rad M,Shokri F,et al.The interplay between vitamin D and viral infections. Rev Med Virol. 2019 Mar;29(2):e2032. [10] Kim J, Yang YL, et al. Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity. Virol J. 2018 Aug 8;15(1):124. [11] L Bishop E, Ismailova A, et al. Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti-Inflammatory. JBMR Plus. 2020 Sep 15;5(1):e10405. [12] Wei R, Christakos S. Mechanisms Underlying the Regulation of Innate and Adaptive Immunity by Vitamin D. Nutrients. 2015 Sep 24;7(10):8251-60. [13] Wu D, Lewis ED, Pae M, et al. Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance. Front Immunol. 2019 Jan 15;9:3160. [14] Gallo D, Baci D, et al. How Does Vitamin D Affect Immune Cells Crosstalk in Autoimmune Diseases? Int J Mol Sci. 2023 Feb 28;24(5):4689. [15] Colotta F, Jansson B, Bonelli F. Modulation of inflammatory and immune responses by vitamin D. J Autoimmun. 2017 Dec;85:78-97. [16] Chen S, Sims GP, et al.. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol. 2007 Aug 1;179(3):1634-47. [17] Bordon Y. Asthma and allergy: Vitamin D primes neonatal immune system. Nat Rev Immunol. 2017 Jul 27;17(8):467. [18] Xiao J, He W. The immunomodulatory effects of vitamin D drops in children with recurrent respiratory tract infections. Am J Transl Res. 2021 Mar 15;13(3):1750-1756. [19] Sun M, Yan Z, Sun R,et al. Dynamic monitoring and a clinical correlation analysis of the serum vitamin A, D, and E levels in children with recurrent respiratory tract infections. Am J Transl Res. 2022 May 15;14(5):3533-3538. [20] Susanna Esposito, et al.Prevention of New Respiratory Episodes in Children with Recurrent Respiratory Infections: An Expert Consensus Statement from the World Association of Infectious Diseases and Immunological Disorders.Microorganisms 2020, 8, 1810. [21] 董晓辉.维生素D对反复呼吸道感染患儿炎症反应及外周血T淋巴亚群的影响.中国实用医刊,2019,46(22):112-114. [22] 杨海军,肖金凤.维生素D对反复呼吸道感染患儿免疫功能和临床疗效的影响.国际流行病学传染病学杂志,2019,46(02):126-130. [23] 贾晓丹,刘阳,宋哲.血清淀粉样蛋白A和25-羟维生素D水平与反复呼吸道感染患儿预后的相关性[J].新乡医学院学报,2023,40(10):955-959.

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