梁熙娟,徐 辉

本文综述了烟草依赖领域在脑结构和功能磁共振成像（fMRI）技术方面的最新研究进展。研究揭示，长期吸烟与大脑前额叶、扣带回、岛叶等关键区域的灰质体积减少及功能连接异常密切相关，这些改变涉及奖赏处理、认知控制及情绪调节等神经环路。fMRI进一步展示了吸烟渴求、吸烟行为触发时特定脑区的激活模式。这些发现不仅深化了对烟草依赖神经机制的理解，也为制定个性化戒烟策略提供了科学依据。

功能磁共振成像；脑结构；脑功能；烟草依赖

[1] 董安珂,张勇,程敬亮,等.轻度尼古丁依赖对人体大脑灰质结构影响的MRI评价[J].放射学实践,2018,33(04):354-358. [2] Elbejjani M,Auer R,Jacobs DR Jr,Haight T,Davatzikos C,Goff DC Jr,Bryan RN,Launer LJ.Cigarette smoking and gray matter brain volumes in middle ageadults:the CARDIA Brain MRI substudy[J].Transl Psychiatry.2019,11;9(1):78. [3] Conti AA,Baldacchino AM.Chronic tobacco smoking,impaired reward-based decision-making,and role of insular cortex:A comparison between early-onset smokers and late-onset smokers[J].Front Psychiatry.2022,26;13:939707. [4] 胡赢凡.尼古丁依赖脑结构变化的磁共振成像研究[D].中国科学院大学(中国科学院精密测量科学与技术创新研究院),2021. [5]张勇,汪卫建,董安珂,等.尼古丁依赖者脑白质微结构改变的DTI评价[C].中国控制吸烟协会.中国控制吸烟协会第19届全国控烟学术研讨会论文摘要.郑州大学第一附属医院磁共振科,2018:2. [6] Huang H,Zhang Y,Cheng J,Wang W,Wen M.Evaluating the Changes of White Matter Microstructures in Tobacco Addicts Based on Diffusion Tensor Imaging[J].Med Sci Monit.2020,3;26:e919105. [7] Ghahremani DG,Pochon JF,Diaz MP,Tyndale RF,Dean AC,London ED.Nicotine dependence and insula subregions:functional connectivity and cue-induced activation[J].Neuropsychopharmacology.2023;48(6):936-945. [8] Qiu X,Han X,Wang Y,Ding W,Sun Y,Zhou Y,Lei H,Lin F.Interaction Between Smoking and Internet Gaming Disorder on Spontaneous Brain Activity[J].Front Psychiatry.2020,3;11:586114. [9] Zheng H,Zhai T,Lin X,Dong G,Yang Y,Yuan TF.The resting-state brain activity signatures for addictive disorders[J].Med.2024,8;5(3):201-223.e6. [10] Wen M,Yang Z,Wei Y,Huang H,Zheng R,Wang W,Gao X,Zhang M,Fang K,Zhang Y,Cheng J,Han S.More than just statics:Temporal dynamic changes of intrinsic brain activity in cigarettesmoking[J].Addict Biol.2021;26(6):e13050.

点击下载PDF