作者
丁云豪,马臻棋
文章摘要
HnRNP A2B1是核内不均一核糖核蛋白(HnRNPs)家族中的核心组成成分,具有多种功能,包括翻译后修饰、细胞信号转导、与多种DNA、RNA及蛋白质的直接相互作用或与它们形成复合物。本文就HnRNP A2B1在肺癌、肝癌及乳腺癌中的研究进展作一综述。
文章关键词
核内不均一核糖核蛋白;HnRNP A2B1;恶性肿瘤
参考文献
[1] Li Z,Chen Q,,et al.Novel Pathological Role of hn RNPA1 in Vascular Smooth Muscle Cell Function and Neointima Hy perplasia[J].Arterioscler Thromb Vasc Biol,2017,37.
[2] celo,C.,Etchin,J.et al.(2014).Ribonucleoprotein NRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells.Gastroenterology,147(4),882–892.e888.
[3] Zuccotti P,Colombrita C,et al.HnRNP A2/B1 and NELAV proteins bind to a specific U-rich element in CDK5R1 3-UTR and oppositely regulate its expression[J].Biochim Biophys Acta,2014(39):506-516.
[4] iu Y,Shi SL.The roles of HnRNP A2B1 in RNA biology and disease.Wiley Interdiscip Rev RNA.2021;12(2):e1612.
[5] Fielding P,Turnbull L,et al.Heterogeneous nuclear ribonucleoprotein A2/B1 up-regulation in bronchial lavage specimens:a clinical marker of early lung cancer detection.Clin Cancer Res.1999 Dec;5(12):4048-52.
[6] Tockman MS,Mulshine JL,et al.Prospective detection of preclinical lung cancer:results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression.Clin Cancer Res.1997 Dec;3(12 Pt 1):2237-6.
[7] Dai L,Li J,et al.Identification of autoantibodies to ECH1 and HNRNP A2B1 as potential biomarkers in the early detection of lung cancer.Oncoimmunology.2017 Mar 31;6(5):e1310359.
[8] Sueoka E,Sueoka N,et al.Heterogeneous nuclear ribonucleoprotein B1 as early cancer biomarker for occult cancer of human lungs and bronchial dysplasia.Cancer Res.2001 Mar 1;61(5):1896-902.
[9] Qu XH,Liu JL,et al.Insights into the roles of HnRNP A2B1 and AXL in non-small cell lung cancer.Oncol Lett.2015 Sep;10(3):1677-1685.
[10] Xuan Y,Wang J,Ban L,et al.HnRNP A2B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers.Mol Oncol.2016 Apr;10(4):610-24.
[11] Tauler J,Zudaire E,et al.HnRNP A2B1 modulates epithelial-mesenchymal transition in lung cancer cell lines.Cancer Res.2010 Sep 15;70(18):7137-47.
[12] Hung CY,Wang YC,et al.Nm23-H1-stabilized HnRNP A2B1 promotes internal ribosomal entry site(IRES)-mediated translation of Sp1 in the lung cancer progression.Sci Rep.2017 Aug 22;7(1):9166.
[13] Kim MK,Choi MJ,et al.Heterogeneous nuclear ribonucleoprotein A2/B1 regulates the ERK and p53/HDM2 signaling pathways to promote the survival,proliferation and migration of nonsmall cell lung cancer cells.Oncol Rep.2021 Aug;46(2):153.
[14] Li C,Qin F,et al.HnRNP A2B1-Mediated Extracellular Vesicles Sorting of miR-122-5p Potentially Promotes Lung Cancer Progression.Int J Mol Sci.2021 Nov 28;22(23):12866.
[15] Yao Y,Chen C,et al.Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization. J Exp Clin Cancer Res.2023 Dec 5;42(1):330.
[16] Diao X,Guo C,Zheng H,et al.SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer.Signal Transduct Target Ther.2023 Nov 4;8(1):426.
[17] Bian W,Yu H,Zhang X,et al.Particulate matters 2.5 induce tumor progression in lung cancer by increasing the activity of HnRNP A2B1 resulting in retarding mRNA decay of oxidative phosphory lation.IUBMB Life.2024 Aug;76(8):563-576.
[18] Cui H,Wu F,et al.Up-regulation and subcellular localization of HnRNP A2B1 in the development of hepatocellular carcinoma.BMC Cancer.2010 Jul 6;10:356.
[19] Mizuno H,Honda M,et al.Heterogeneous nuclear ribonucleoprotein A2/B1 in association with hTERT is a potential biomarker for hepatocellular carcinoma.Liver Int.2012 Aug;32(7):1146-55.
[20] Zhou ZJ,Dai Z,et al.Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma.Int J Cancer.2013 Mar 1;132(5):1080-9.
[21] Shilo A,Ben Hur V,et al.Splicing factor HnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development.RNA.2014 Apr;20(4):505-15.
[22] Zhou ZJ,Dai Z,et al.HNRNP AB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL.Cancer Res.2014 May 15; 74(10):2750-62.
[23] Wang H,Liang L,Dong Q,et al.Long noncoding RNA miR503HG,a prognostic indicator,inhibits tumor metastasis by regulating the HNRNP A2B1/NF-κB pathway in hepatocellular carcinoma.Theranostics.2018 Apr 15;8(10):2814-2829.
[24] Yang Y,Chen Q,et al.HNRNP AB-regulated lncRNA-ELF209 inhibits the malignancy of hepatocellular carcinoma.Int J Cancer.2020 Jan 1;146(1):169-180.
[25] Wen Z,Lian L,et al.LncRNA ANCR promotes hepatocellular carcinoma metastasis through upregulating HNRNP A1 expression.RNA Biol.2020 Mar;17(3):381-394.
[26] Wang G,Zhang X,et al.CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating HnRNP A2B1-nmMYLK axis.Cell Death Dis.2021 Sep 29;12(10):891.
[27] Chen T,Gu C,et al.LncRNA-uc002mbe.2 Interacting with HnRNP A2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells.Front Pharmacol.2017Sep25;8:669.
[28] Hu Y,Sun Z,Deng J,et al.Splicing factor HnRNP A2B1 contributes to tumorigenic potential of breast cancer cells through STAT3 and ERK1/2 signaling pathway[J].Tu mour Biol,2017,39(3):1010428317694318.
[29] Ma Y,Yang L,Li R.HnRNP A2B1 Is a Novel Prognostic Biomarker for Breast Cancer Patients.Genet Test Mol Biomarkers.2020 Nov;24(11):701-707.
[30] Ayoufu A,Yi L,Tuersuntuoheti M,Li Y.HNRNP A2B1 is a potential biomarker of breast cancer related to prognosis and immune infiltration.Aging(Albany NY).2023 Sep 5;15(17):8712-8728.
[31] Jin T,Yang L,Chang C,et al.HnRNP A2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development.Adv Sci(Weinh).2024 Jun;11(24): e2307639.
Full Text:
DOI