常勇锋,杨生森

食管癌是全球最常见的癌症之一，其中进展期食管癌大多预后较差。因此，明确肿瘤的分子机制，为早期诊治和靶向治疗提供候选分子是食管癌研究的主流思路。在本文中，我们讨论与肿瘤相关的信号分子，即TMED3、KIF4A、SH2D4A和USP，它们在肿瘤进展中的发挥的作用，并进一步讨论了这些信号分子的作用机制。从而分析其在食管癌中诊断和治疗的潜能。

食管鳞状细胞癌；跨膜emp24结构域蛋白3；驱动蛋白超家族4A

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