陈清华,任 明

随着冠心病（CHD）发病率和死亡率的不断攀升，经皮冠状动脉介入治疗（PCI）术已成为治疗冠心病的重要手段。然而PCI术对血管内皮的损伤日益受到关注。最新研究表明这种损伤与G蛋白偶联受体56（GPR56）和前蛋白转化酶枯草溶菌素9（PCSK9）的表达量变化密切相关，并且它们在血小板活化的病理过程中发挥着关键作用。本文综述了PCI术后GPR56和PCSK9与血小板活化的关系，旨在为PCI术后ISR的预防和治疗提供有益参考。

经皮冠状动脉介入治疗术（PCI）；G蛋白偶联受体56（GPR56）；前蛋白转化酶枯草溶菌素9（PCSK9）；血小板活化

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