蔺小洲,何永好,杜 鑫,赵建晨,李春亮

随着高能、高速创伤因素的增加以及老龄化的加剧，骨和软骨损害和退变的病例日渐增多。由于关节软骨缺乏血管、神经和淋巴组织，其自我修复能力有限，受伤后的恢复成为临床亟待解决的问题。因此，积极寻求骨软骨的治疗方式是防治骨软骨损伤的关键。研究人员一直在寻找新的生物材料用于骨软骨损伤的替代治疗，尽管已经采用了许多不同性质的材料制造骨软骨替代品，但各个材料之间的性质各有差异，修复效果尚不完全令人满意。骨软骨组织工程技术的提出，为骨软骨损伤同步修复提供了新的治疗方式。本文对骨软骨组织工程技术在软骨损伤修复的研究进展进行简要综述。

骨软骨损伤；组织工程；种子细胞；生长因子；骨软骨支架

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