王建沣,王学红,付明月,周 静

【摘 要】：在中国乃至世界范围内，胃癌均为高发恶性肿瘤之一。B7-H3（CD276）近年来被发现在包括胃癌在内的各种恶性肿瘤中高表达，且其可溶性形式sB7-H3在肿瘤人群血清中亦处于升高状态。目前多认为B7-H3在肿瘤发生发展中主要介导负性免疫应答，且参与肿瘤侵袭转移、上皮间质转化、血管生成、干细胞增殖、糖代谢、耐药及抗肿瘤细胞凋亡等。研究B7-H3与胃癌发生的相关性及其作用机制，有望为胃癌患者的早期诊治拓展新的思路。

【关键词】：B7-H3；CD276；胃癌；肿瘤免疫；免疫逃逸；机制研究

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