廖茂洁

【摘 要】：目前，肺癌是全世界范围内癌症相关死亡的主要原因。而早诊早治是提高早期肺癌患者生存率的关键，但肺癌早期诊治策略仍有许多问题亟需解决，如肺结节良恶性的鉴别判断尚欠精准。甲基化通过检测特定基因的甲基化状态，提供分子水平的诊断信息；影像组学则通过高通量提取医学影像特征，反映结节的宏观结构和功能特性。将甲基化和影像组学相结合，可以从分子和影像两个层面综合分析肺结节的良恶性，显著提高诊断的准确性和可靠性。本文旨在对甲基化联合影像组学对早期肺癌辅助精准诊断中的应用现状进行综述。

【关键词】：肺结节；甲基化；影像组学；联合检测

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