郑继铭,刘海洋

舒更葡糖钠是甾类肌松药特异性拮抗剂，影响甾类肌松药再分布，加速其在神经肌肉接头处与烟碱样乙酰胆碱受体分离，达到快速恢复神经肌肉功能的目的。适用临床麻醉中重症肌无力、呼吸系统疾病、老年人、儿童、全麻剖宫产、肥胖患者等肌松效果的消除。本文对其药理作用、临床应用、安全性及潜在风险进行综述。

舒更葡糖钠；罗库溴铵；维库溴铵；肌松拮抗

[1] Carron M,Zarantonello F,Lazzarotto N,Tellaroli P,Ori C.Role of sugammadex in accelerating postoperative discharge:A meta-analysis.J Clin Anesth.2017.39:38-44. [2] Paton F,Paulden M,Chambers D,et al.Sugammadex compared with neostigmine/glycopyrrolate for routine reversal of neuromuscular block:a systematic review and economic evaluation.Br J Anaesth.2010.105(5):558-67. [3] Thompson CA.Sugammadex approved to reverse NMBA effects.Am J Health Syst Pharm.2016.73(3):100. [4] 韩斌,车向明,白云波.舒更葡糖的临床应用进展.医学综述.2021.27(02):375-379. [5] 李凯,赵国庆,李亮.舒更葡糖的应用进展.麻醉安全与质控.2019.3(04):236-239. [6] West JB.A new approach to very-high-altitude land travel:the train to Lhasa,Tibet.Ann Intern Med.2008.149(12):898-900. [7] Gijsenbergh F,Ramael S,Houwing N,van Iersel T.First human exposure of Org 25969,a novel agent to reverse the action of rocuronium bromide.Anesthesiology.2005.103(4):695-703. [8] Pühringer FK,Gordon M,Demeyer I,et al.Sugammadex rapidly reverses moderate rocuronium-or vecuronium-induced neuromuscular block during sevoflurane anaesthesia:a dose-response relationship.Br J Anaesth.2010.105(5):610-9. [9] Kam PJ,Heuvel MW,Grobara P,et al.Flucloxacillin and diclofenac do not cause recurrence of neuromuscular blockade after reversal with sugammadex.Clin Drug Investig.2012.32(3):203-12. [10] Sørensen MK,Bretlau C,Gätke MR,Sørensen AM,Rasmussen LS.Rapid sequence induction and intubation with rocuronium- sugammadex compared with succinylcholine:a randomized trial.Br J Anaesth.2012.108(4):682-9. [11] Williamson RM,Mallaiah S,Barclay P.Rocuronium and sugammadex for rapid sequence induction of obstetric general anaesthesia.Acta Anaesthesiol Scand.2011.55(6):694-9. [12] Nagai T,Matsui H,Fujioka H,et al.Low-Dose vs Conventional-Dose Trimethoprim-Sulfamethoxazole Treatment for Pneumocystis Pneumonia in Patients Not Infected With HIV:A Multicenter, Retrospective Observational Cohort Study.Chest.2024.165(1):58-67. [13] Hashimoto M,Sato Boku A,Tachi N,et al.Two Cases of Rocuronium-Induced Anaphylaxis/Anaphylactic Shock Successfully Treated With Sugammadex.Anesth Prog.2019.66(3):151-155. [14] Zhong W,Ji Z,Sun C.A Review of Monitoring Methods for Cerebral Blood Oxygen Saturation.Healthcare(Basel).2021.9(9). [15] Dong SW,Mertes PM,Petitpain N,et al.Hypersensitivity reactions during anesthesia.Results from the ninth French survey(2005-2007). Minerva Anestesiol.2012.78(8):868-78. [16] De La Cruz I,Errando C,Calaforra S.Treatment of Anaphylaxis to Rocuronium with Sugammadex:A Case Report with Bronchospasm as the Only Symptom.Turk J Anaesthesiol Reanim.2019.47(1):69-72. [17] Amao R,Zornow MH,Cowan RM,Cheng DC,Morte JB,Allard MW.Use of sugammadex in patients with a history of pulmonary disease.J Clin Anesth.2012.24(4):289-97. [18] Martini CH,Boon M,Bevers RF,Aarts LP,Dahan A.Evaluation of surgical conditions during laparoscopic surgery in patients with moderate vs deep neuromuscular block.Br J Anaesth.2014.112(3):498-505. [19] Kim HJ,Lee K,Park WK,et al.Deep neuromuscular block improves the surgical conditions for laryngeal microsurgery.Br J Anaesth.2015.115(6):867-72. [20] Ledowski T,Falke L,Johnston F,et al.Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade:sugammadex,neostigmine or no reversal.Eur J Anaesthesiol.2014.31(8):423-9. [21] Brueckmann B,Sasaki N,Grobara P,et al.Effects of sugammadex on incidence of postoperative residual neuromuscular blockade:a randomized,controlled study.Br J Anaesth.2015.115(5):743-51. [22] Parks KR,Kuo YH,Davis JM,O'Brien B,Hagopian EJ.Laparoscopic versus open liver resection:a meta-analysis of long-term outcome. HPB(Oxford).2014.16(2):109-18.

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