马君慧,郭 佳,李舒敏,白玉芳

胎膜早破（premature rupture of the membranes，PROM）是指临产前的胎膜自然破裂，PROM可导致新生儿呼吸窘迫综合征、绒毛膜羊膜炎、胎盘早剥、败血症、早产等。核苷酸结合寡聚化结构域（nucleotide-blindin oligomerization domain，NOD）样受体是位于细胞质的模式识别受体，可以启动和调节炎症反应。NOD样受体（Nod-like receptors，NLRs）在介导，防御细菌、病毒等病原体感染及调节机体炎症反应中起关键作用。NLRs主要介导NF-κB通路、MAPK通路，参与免疫应答。有研究显示NOD1、NOD2存在于妊娠相关组织中，NOD1、NOD2介导NF-κB或MAPK途径的激活，可促进炎症因子释放、细胞外基质降解及胎膜细胞凋亡引发PROM。我们已经研究发现MMP-2、3、9在PROM发生过程中起关键作用，而NOD1、NOD2作为上游信号因子可能也在胎膜早破的发生中发挥了重要作用，现就NOD1、NOD2与胎膜早破的相关性进行综述，已期对胎膜早破的发生机制有进一步认识。

核苷酸结合寡聚化结构域样受体1；核苷酸结合寡聚化结构域样受体2；胎膜早破；相关性

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