刘 洁,张淑坤,宋亚斌,吴世政

目的：研究不同海拔健康成年人脑血管收缩[脑血管反应性（cerebrovascular reactivity，CVR）]的差异及急进高海拔后脑血管反应性的变化，探讨引起CVR差异和急进高原后变化的可能机制。方法：经颅多普勒结合CO2吸入检测CVR，近红外光谱技术（NIRS）测量局部脑氧饱和度（regional cerebral oxygen saturation，rScO2），同时采集血标本检测血常规、血液流变学，采用酶联免疫吸附法测定血清中血管活性物质。受试者共59人分三组，低海拔组（北京44.4m）从北京当地乘飞机急进中度海拔（西宁2200 m），出发前及到达后24小时，行各项指标检测。休息48h后与中海拔组（西宁2200 m）受试者一同从西宁乘飞机急进高海拔（玉树结古镇3700 m），到达后24小时及48小时检测各项指标。中海拔组在西宁市出发前采集各项指标数据，高海拔组各项指标与低海拔组、中海拔组在到达玉树48h后一同采集。

急进高原；脑血管反应性；局部脑氧饱和度；血管活性物质

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