雷鹏鹏

阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与心血管疾病具有显著相关性，OSAHS可在睡眠状态下诱发机体出现间歇缺氧和高碳酸血症发生，然后通过氧化应激、炎症反应和肠道菌群紊乱途径引起内皮损伤、促进血液高凝发生以及影响代谢功能等一系列过程加剧心血管疾病的发生和发展。OSAHS的发病率一直处于高水平，通过对于OSAHS的诱发心血管疾病的相关机制的研究，也为治疗OSAHS提供新的途径，也可改善睡眠治疗、减少心血管疾病的发生以及提高临床有效的治疗。

阻塞性睡眠呼吸暂停低通气综合征；间歇性缺氧；氧化应激；炎症反应；肠道菌群紊乱

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