李宝睿,苏 娟

血小板免疫样受体糖蛋白VI（GPVI）和C型凝集素受体2（CLEC-2）可以在止血、发育、宿主防御、炎症和组织修复中发挥重要作用，其通过基于免疫受体酪氨酸的活化基序（ITAM）发出信号。GPVI被内皮下基质中的胶原蛋白、血栓中的纤维蛋白和纤维蛋白原以及大量其他配体激活。CLEC-2可被跨膜蛋白Podoplanin激活，其在血管系统外发现，在发育、炎症和癌症中上调，在这篇综述中，我们讨论了CLEC-2和GPVI的生理和病理作用及其作为促炎和抗炎中的表达及其意义。

免疫样受体糖蛋白VI（GPVI）；C型凝集素受体2（CLEC-2）；慢性炎症

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