刘镇瑜,陈凤琴

本文综合讲述了儿童肺炎支原体感染的研究现状，包括其临床表现与诊断方法、治疗与预防策略，以及未来研究方向及展望。通过系统梳理相关文献，本文总结了儿童肺炎支原体感染的传统与新型诊断技术的优缺点、抗生素治疗及耐药性。此外，本文还探讨了疫苗接种的可行性。最后，本文指出了当前研究中存在的问题，如诊断方法的最新前沿、治疗策略的个体化与耐药性挑战，并对未来研究及展望展开叙述，为儿童肺炎支原体感染预防及治疗提供方向及思路。

儿童，肺炎支原体感染；研究进展；新型技术；耐药性

[1] Waites KB , Xiao L , Liu Y ,et al. Mycoplasma pneumoniae from the respiratory tract and beyond[J]. Clin Microbiol Rev, 2017,30(3). [2] JacobsE,EhrhardtI,DumkeR.New in sights intheout break part ternof Mycoplasmapneumoniae[J].IntJMEDmICROBIOL,2015,305(7). [3] LloensK, GoossensH, IevenM. Acute respiratory tract infection caused by Pneumocystis pneumonia: current status of diagnostic methods[J]. European Clinical Journal Microbial Infection Diss, 2010, 29 (9). [4] Kumar S.Mycoplasma pneumoniae:A significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections[J].Indian J Med Res,2018,147(1):23-31. [5] Waris ME, Toikka P, Saarinen T, et al.. Diagnosis of Mycoplasma pneumoniae pneumonia in children. J Clin Microbiol. 1998;36(11) [6] Qu J,Zhang J,Chen Y,et al.Aetiology of severe community acquired pneumonia in adults identified by combined detection methods:a multi-centre prospective study in China[J].Emerg Microbes Infect,2022,11(1). [7] Gao L, Sun Y. Laboratory diagnosis and treatment of Mycoplasma pneumoniae infection in children: a review. Ann Med. 2024;56(1). [8] Loens K, Beck T, Ursi D, et al.. Development of real-time multiplex nucleic acid sequence-based amplification for detection of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella spp. in respiratory specimens. J Clin Microbiol. 2008;46(1). [9] Li W,Fang YH,Shen HQ,et al.Evaluation of a realtime method of simultaneous amplification and testing in diagnosis of Mycoplasma pneumoniae infection in children with pneumonia[J].PLoS One,2017,12(5). [10] Wilson MR,O'Donovan BD,Gelfand JM,et al.Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing[J]. JAMA Neurol,2018,75(8):947-955. [11] Gardiner SJ, Gavranich JB, Chang AB. Antibiotics for community-acquired lower respiratory tract infections secondary to Mycoplasma pneumoniae in children. Cochrane Database Syst Rev. 2015;1. [12] China JAPPplClinPediatr, August 2021, VOOL. 36, NO. 16. [13] CaoB, QUJCX, YinYD, et al. Overview of antimicrobial selection for pneumocystis pneumonia: focus on macrolide resistance[J]. RESSPIIRJ, 2017, 11(4): 419-429. [14] Morozumi M, Takahashi T, Ubukata K. Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia. J Infect Chemother. 2010;16:78–86. [15] Ishiwada N, Shinjoh M, Kusama Y, Arakawa H, Ohishi T, Saitoh A, et al. Guidelines for the management of respiratory infectious diseases in children in Japan 2022. Pediatr Infect Dis J. 2023;42:e369–76. [16] Cross R, Ling C, Day NP, McGready R, Paris DH. Revisiting doxycycline in pregnancy and early childhood—time to rebuild its reputation? Expert Opin Drug Saf. 2016;15:367–82. [17] Poyhonen H, Nurmi M, Peltola V, Alaluusua S, Ruuskanen O, Lahdesmaki T. Dental staining after doxycycline use in children. J Antimicrob Chemother. 2017;72:2887–90. [18] Editing Group for Multidisciplinary Expert Consensus on the Rational Use of Tetracyclines Commonly Used in Clinical Practice, Hospital Infection Control Branch of Chinese Preventive Medicine Association, Clinical Pharmacology Branch of Chinese Pharmacological Society. Multidisciplinary expert consensus on the rational use of tetracyclines commonly used in clinical practice. Zhonghua Yi Xue Za Zhi. 2023;103:2281–96. [19] Linchevski, I.; Klement, E.; Nir-Paz, R. Mycoplasma pneumoniae vaccine protective efficacy and adverse reactions–systematic review and meta-analysis. Vaccine 2009, 27, 2437–2446. [20] Cimolai, N.; Cheong, A.C.; Morrison, B.J.; Taylor, G.P. Mycoplasma pneumoniae reinfection and vaccination: Protective oral vaccination and harmful immunoreactivity after re-infection and parenteral immunization. Vaccine 1996, 14, 1479–1483. [21] Wang Y, Wang Y, Quan S, Jiao W, Li J, Sun L, Wang Y, Qi X, Wang X, Shen A. Establishment and Application of a Multiple Cross Displacement Amplification Coupled With Nanoparticle-Based Lateral Flow Biosensor Assay for Detection of Mycoplasma pneumoniae. Front Cell Infect Microbiol. 2019 Sep 23;9:325.

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