王静雯,王 敏,孟 月,许慧宁

每年我国有超过100万人因慢性阻塞性肺疾病而死亡，并且大约有500万人因此导致残疾，COPD患者急性发作同病死率具有直接联系，患者急性发作次数越多，其死亡风险就越大。COPD病情的加重会导致机体血清25-（OH）D3水平下降，其原因可能与维生素D的缺乏会加重骨质疏松症状，导致肺通气不足进而影响病情有关。因此深入探讨老年COPD急性加重期患者及与血清25-（OH）D3的关系，发病机理以及危险因素、治疗措施，对防治该病的不良预后，以及指导临床安全合理用药具有重要意义，以期为优化治疗提供新的研究思路。

慢性阻塞性肺疾病；慢性阻塞性肺疾病急性加重；维生素D；血清25-（OH）D3

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