陈 萍

精准医疗是一种基于患者个体基因组学、分子生物学和临床特征，通过多组学技术和人工智能算法为患者提供个性化诊断与治疗方案的医疗模式。随着数字病理学、分子病理学及多模态人工智能诊断技术的发展，精准医疗在肿瘤个体化治疗中展现了巨大的应用前景。本文重点探讨精准医疗在肿瘤诊断、治疗和预后评估中的具体应用，梳理多组学融合分析和人工智能技术的最新进展，并展望未来发展方向。

精准医疗；肿瘤；个体化治疗；人工智能；多组学

[1] Tizhoosh HR,Pantanowitz L.Artificial intelligence and digital pathology:challenges and opportunities.J Pathol Inform,2018,9:38. [2] Aeffner F,Zarella MD,Buchbinder N,et al.Introduction to digital image analysis in whole-slide imaging:a white paper from the Digital Pathology Association.J PatholInform,2019,10:9. [3] Srinidhi CL,Ciga O,Martel AL.Deep neural network models for computational histopathology:a survey.Med Image Anal,2021,67:101813. [4] Bhinder B,Gilvary C,Madhukar NS,et al.Artificial intelligence in cancer research and precision medicine.Cancer Discov,2021,11:900-15. [5] Kann BH,Hosny A,Aerts H.Artificial intelligence for clinical oncology.Cancer Cell,2021,39:916-27. [6] Browning L,Colling R,Rakha E,et al.Digital pathology and artificial intelligence will be key to supporting clinical and academic cellular pathology through COVID-19 and future crises:the PathLAKE consortium perspective.J Clin Pathol,2021,74:443-47. [7] Feng M,Deng Y,Yang L,et al.Automated quantitative analysis of Ki-67 staining and HE images recognition and registration based on whole tissue sections in breast carcinoma.Diagn Pathol,2020,15:65. [8] Pantanowitz L,Quiroga-Garza GM,Bien L,et al.An artificial intelligence algorithm for prostate cancer diagnosis in whole slide images of core needle biopsies:a blinded clinical validation and deployment study.Lancet Digit Health,2020,2:e407-16. [9] Kanavati F,Tsuneki M.A deep learning model for gastric diffuse-type adenocarcinoma classification in whole slide images.Sci Rep, 2021,11:20486. [10] Shen B,Zhang Z,Shi X,et al.Real-time intraoperative glioma diagnosis using fluorescence imaging and deep convolutional neural networks.Eur J Nucl Med Mol Imaging,2021,48:3482-92. [11] Peng W,Chen S,Kong D,et al.Grade diagnosis of human glioma using Fourier transform infrared microscopy and artificial neural network.Spectrochim Acta A Mol Biomol Spectrosc,2021,260:119946.

点击下载PDF