文 佳,刘乙霖,张云桥,游 旭,曾 勇

精神分裂症（Schizophrenia，SCZ）是一种较为严重的精神疾病，该病的影响范围广泛，全球约1%的人口受其影响，如今，越来越多的研究揭示了SCZ的病因和发病机制可能与外泌体microRNA（miRNAs）有关。本文主要阐述了外泌体来源的miRNAs在精神分裂症中的作用，阐明其潜在的作用机制，并评估关于外泌体miRNAs作为精神分裂症的生物标志物的可行性，以及其有望成为精神分裂症诊断和治疗新依据的可能性。

精神分裂症；外泌体；miRNA

[1] Faden J,Citrome L.Schizophrenia:One Name,Many Different Manifestations.Med Clin North Am.2023 Jan;107(1):61-72. [2] Rybakowski J.Etiopathogenesis of schizophrenia-the state of the art for 2021.Psychiatr Pol.2021 Apr 30;55(2):261-274.English,Polish. [3] Krylova SV,Feng D.The Machinery of Exosomes:Biogenesis,Release,and Uptake.Int J Mol Sci.2023 Jan 10;24(2):1337. [4] Komatsu S,Kitai H,Suzuki HI.Network Regulation of microRNA Biogenesis and Target Interaction.Cells.2023 Jan 13;12(2):306. [5] Yapijakis C.Regulatory Role of MicroRNAs in Brain Development and Function.Adv Exp Med Biol.2020;1195:237-247. [6] Jakubec M,Maple-Grødem J,Akbari S,Nesse S,HalskauØ,Mork-Jansson AE.Plasma-derived exosome-like vesicles are enriched in lyso-phospholipids and pass the blood-brain barrier.PLoS One.2020 Sep 21;15(9):e0232442. [7] Khadimallah I,Jenni R,Cabungcal JH,Cleusix M,Fournier M,Beard E,Klauser P,Knebel JF,Murray MM,Retsa C,Siciliano M,Spencer KM,Steullet P,Cuenod M,Conus P,Do KQ.Mitochondrial,exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons,psychopathology,and neurocognition in schizophrenia.Mol Psychiatry.2022 Feb;27(2):1192-1204. [8] Du Y,Yu Y,Hu Y,Li XW,Wei ZX,Pan RY,Li XS,Zheng GE,Qin XY,Liu QS,Cheng Y.Genome-Wide,Integrative Analysis Implicates Exosome-Derived MicroRNA Dysregulation in Schizophrenia.Schizophr Bull.2019 Oct 24;45(6):1257-1266.

点击下载PDF