张馨予,霭嘉琪,龚天玥,庞俊莹,郑楠永

目的：通过网络药理学和分子对接研究逍遥散改善肝细胞癌索拉非尼耐药的活性成分、潜在靶点及作用机制。方法：利用TCMSP和PubChem数据库筛选逍遥散活性成分及靶点，结合GeneCards和GEO数据库获取耐药相关靶基因，取交集靶点。通过String构建PPI网络，用Cytoscape筛选核心靶点，并通过Metascape进行GO和KEGG富集分析。结果：逍遥散筛选出161个活性成分，176个交集靶点（如TP53、Akt1、STAT3、MAPK1），关键通路包括MAPK和PI3K-Akt，槲皮素等为核心成分。结论：逍遥散通过多靶点和通路调节，改善肝细胞癌索拉非尼耐药。

逍遥散；肝细胞癌；网络药理学；索拉非尼

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