黄雪苗

目的分析妊娠期糖尿病患者血清葡萄糖依赖性促胰岛素释放肽（GIP）、成纤维细胞生长因子-23（FGF23）水平与产后糖代谢异常的关系。方法选取在我产检并分娩的200例妊娠期糖尿病产妇，在孕妇确诊为妊娠糖尿病时检测GIP、FGF23，根据本组孕产妇产后是否发生糖代谢异常将其分为异常组（50例）、正常组（150例），对比两组GIP、FGF23水平，探讨GIP、FGF23对妊娠期糖尿病患者产后糖代谢异常的预测价值。结果异常组孕GIP显著低于正常组，FGF23水平显著高于正常组（P<0.05），person相关性分析结果表明，GIP与妊娠期糖尿病患者产后糖代谢异常呈负相关（r=-0.276），FGF23与妊娠期糖尿病患者产后糖代谢异常呈正相关（r=0.399）。GIP、FGF23预测妊娠期糖尿病患者产后糖代谢异常的曲线下面积(AUC)分别为0.722、0.631，联合预测妊娠期糖尿病患者产后糖代谢异常的AUC为0.877，比GIP、FGF23单独预测的价值更高（P<0.05）。结论GIP、FGF23与妊娠期糖尿病患者产后糖代谢异常密切相关，因此在妊娠糖尿病的防治中积极加强GIP、FGF23水平监测。

GIP；FGF23；妊娠期糖尿病；糖代谢异常；相关性

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