杨 兰

早发型败血症（Early-Onset Sepsis EOS）在新生儿重症监护病房（Neonatal Intensive Care Unit，NICU）中病死率高，可能对幸存者带来不同程度的长期损失，因此及时诊断和合理使用抗生素对降低EOS相关死亡率和发病率尤为重要。目前早发型败血症的诊断是临床表现、非特异性生物标志物和血培养的组合。传统的生物标志物如降钙素（PCT）、C-反应蛋白（CRP）等敏感性和特异性较差。为了帮助新生儿科医生准确、快速地识别败血症新生儿，需要有足够敏感性和特异性的EOS生物标志物，所以寻找成本效益高、可靠和早期预测因子也成为研究的热点。因此，本文查阅关于EOS的生物学标记物最新文献，并对其相关指标进行检索，为临床早期识别EOS提供更佳的参考指标。

新生儿；早发型败血症；生物标记物；分子技术

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