赵俊杰,武 艺,田 祺,张 宇,曹俊伟

病毒感染引发的突发传染病对人类健康和社会稳定构成严重威胁。氧化应激作为活性氧（ROS）与抗氧化系统失衡的病理状态，在病毒感染中发挥双重作用。一方面，ROS可通过直接破坏病毒或激活免疫应答抑制感染；另一方面，过度的氧化应激可能被病毒利用，促进其复制和传播。本文为主要从以上两个方面阐述氧化应激对病毒感染的影响机制。

氧化应激；ROS；病毒感染

[1] Berry R,Watson G M,Jonjic S,et al,Modulation of innate and adaptive immunityby cytomegaloviruses[J].Nat Rev Immunol,2020,20(2):113-27. [2] Cao X.COVID-19:immunopathology and its implications for therapy[J].NatRev Immunol,2020,20(5):269-70. [3] Zhang Y,Xu Y,Lu W,et al.Upregulation ofAntioxidant Capacity and NucleotidePrecursor Availability Sufices for Oncogenic Transformation[J].Cell Metab,2021,33(1):94-109 e8. [4] Meuren LM,Prestes EB,Papa MP,de Carvalho LRP,et al.Infection of Endothelial Cells by Dengue Virus Induces ROS Production by Different Sources Affecting Virus Replication,Cellular Activation,Death and Vascular Permeability.Front Immunol.2022;13:810376. [5] Nasi A,McArdle S,Gaudernack G,et al.Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS- CoV-2 in an ageing population,consider N-acetylcysteine as early therapeutic intervention.Toxicol Rep.2020;7:768-771. [6] Sun R,Sun S,Zhang Y,et al.PCV2 Induces Reactive Oxygen Species To Promote Nucleocytoplasmic Translocation of the Viral DNA Binding Protein HMGB1 To Enhance Its Replication.J Virol.2020 Jun 16;94(13) [7] Li X,Wang M,Cheng A,et al.Enterovirus Replication Organelles and Inhibitors of Their Formation.Front Microbiol.2020;11:1817. [8] Hikmet F,Méar L,EdvinssonÅ,et al.The protein expression profile of ACE2 in human tissues.Mol Syst Biol.2020 Jul;16(7):e9610. [9] Glowacka I,Bertram S,Müller MA,et al.Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response.J Virol.2011 May;85(9):4122-34. [10] Wong LM,Jiang G.NF-κB sub-pathways and HIV cure:A revisit.EBioMedicine.2021 Jan;63:103159. [11] Li M,Yuan H,Yang X,et al.Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis.Cell Biosci.2025 Jan 22;15(1):6. [12] Zhang L,Lin D,Sun X,et al.Crystal structure of SARS-CoV-2 main protease provides a basis for design of improvedα-ketoamide inhibitors.Science.2020 Apr 24;368(6489):409-412. [13] Wu,Y.et al.(2018).HIV-1 Nef promotes viral persistence by inhibiting ROS-induced apoptosis.Nature Microbiology,3(8),939-950. [14] Boudreau,H.E.et al.(2019).HCV core protein suppresses NOX4-dependent ROS production.Journal of Virology,93(5),e01742-18. [15] Chen,X.,Liu,S.,Goraya,M.U.,et al.(2020).Host immune response to influenza A virus infection.Frontiers in Immunology,11,203. [16] Lin,D.L.,Cherepanova,N.A.,Bozzacco,L.,et al.(2019).Zika virus NS5 protein inhibits mitochondrial complex I to suppress ROS production and promote viral replication.Proceedings of the National Academy of Sciences(PNAS),116(37),19107-19112. [17] Huang,C.,Li,Y.,Li,Z.,et al.(2021).**HPV E6/E7 proteins promote oxidative stress and NF-κB activation to inhibit apoptosis in cervical cancer cells**.*Redox Biology*,45,102048. [18] Olagnier,D.et al.(2020).SARS-CoV-2 suppresses NRF2-mediated antioxidant responses.Nature Communications,11,3814. [19] Cheng,Y.L.et al.(2019).DENV NS2B/NS3 protease induces SOD2 upregulation.PLoS Pathogens,15(3),e1007621. [20] Xia,Y.et al.(2018).HBx induces ROS to activate NF-κB.Hepatology,67(6),2187-2201. [21] Zhang,R.et al.(2019).ZIKV NS4A disrupts Golgi via ROS.Journal of Virology,93(8),e00808-19. [22] Zhang,H.,Wang,Y.,Zhu,X.,et al.(2020).CVB3-induced ROS generation promotes viral replication via MLCK-mediated exocytosis. PLoS Pathogens,16(3),e1008391. [23] Kim,S.J.et al.(2020).HCV NS3/4A induces mitochondrial fission.Cell Reports,30(6), [24] Jiang,H.,Zhang,H.,Meng,Q.,et al.(2021).SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70. Cell&Molecular Immunology,18(4),991–993.

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