崔荣晓,杨永成

反流性食管炎（Gastroesophageal Reflux Disease，GERD）与代谢相关性脂肪性肝病（Metabolic Associated Fatty Liver Disease，MAFLD）是两种常见的慢性疾病，两者均与代谢综合征（如肥胖、胰岛素抵抗、血脂异常等）密切相关，近年来其高发病率与共病风险受到广泛关注，两者不仅在流行病学上可能存在显著重叠，也存在共同的病理生理机制。本文综述了两者在流行病学、发病机制及临床管理中的相关性，旨在为综合诊疗策略提供理论依据，以期为临床实践及研究提供参考。

关键词：反流性食管炎；代谢相关性脂肪性肝病；胰岛素抵抗；炎症；肠道菌群

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