作者
郝 铭,卢 冬
文章摘要
白血病的临床表现复杂多样,常见多以发热、出血、进行性贫血及骨关节疼痛等缺乏特异性的表现为首发症状,因此临床上急性淋巴细胞白血病常与急性髓系白血病、再生障碍性贫血、非造血系统的小圆细胞恶性肿瘤、良性感染性疾病混淆。本研究为1例以便后滴血为首发症状的急性B淋巴细胞白血病,临床上容易引起漏诊、误诊,现代医学对疾病诊断及对B淋巴细胞白血病不同基因分型诊断的精准程度,有益于疾病的精准治疗。随着科技的迅猛发展和医学领域的不断创新,大数据和精准医疗正日益成为医学研究和临床实践的重要支柱[1]。本研究一例B-ALL为例展现精准医疗的应用。
文章关键词
B淋巴白血病;精准医疗;基因测序
参考文献
[1] 杜珍武,孙昊炎,石传楷,等.大数据及精准医疗背景下医学研究生所面临的挑战及对策[J].中国实验诊断学,2023,27(10):1250-1253.
[2] 郑静.急性白血病耐药相关基因表达及其与临床关系的研究[D].福建医科大学,2002.
[3] G Esposito,Cevenini A,Cuomo A,et al.Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms[J].Biochem J,2011,438(1):121-131.
[4] 于皎乐,吴敏媛,张瑞东,等.青少年急性淋巴细胞白血病临床特征及预后分析[J].中国实用儿科杂志,2017,32(09):687-692.
[5] K Oshima,Khiabanian H,Da Silva-Almeida-AC,et al.Mutational landscape,clonal evolution patterns,and role of RAS mutations in relapsed acute lymphoblastic leukemia[J].Proc Natl Acad Sci U S A,2016,113(40):11306-11311.
[6] S-J Westra.The communication of the radiation risk from CT in relation to its clinical benefit in the era of personalized medicine:part 2:benefits versus risk of CT[J].Pediatr Radiol,2014,44 Suppl 3525-533.
[7] R Koleva-Kolarova,Buchanan J,Vellekoop H,et al.Financing and Reimbursement Models for Personalised Medicine:A Systematic Review to Identify Current Models and Future Options[J].Appl Health Econ Health Policy,2022,20(4):501-524.
Full Text:
DOI