益生菌在幽门螺杆菌感染铋剂四联根除治疗中的作用及其对肠道菌群失调的影响

ISSN:2705-098X(P)

EISSN:2705-0505(O)

语言:中文

作者
杨吉香,周思思
文章摘要
幽门螺杆菌(Helicobacter pylori,Hp)感染是导致慢性胃炎、胃溃疡和胃癌的重要病因。随着人们对健康重视程度的提高及H.pylori感染筛查、规范根除的推广,H.pylori的全球粗略患病率已从1990年前的52.6%下降到2014年至2023年的42.8%[1-3]。由于我国各地区地理环境、饮食习惯、民族风俗、医疗条件等因素的影响,其感染率存在着较大的地域差异(40%到70%不等)[4-6],其中,西北地区感染率最高为51.3%,青海省患病率达到60.2%。H.pylori感染导致炎症反应、胃肠道黏膜保护屏障破坏及细胞因子损害引起腹痛、腹胀、便秘、腹泻、恶心、呕吐及反酸等一系列非特异性临床症状。铋剂四联疗法是目前治疗Hp感染的主要方法之一,随着抗生素耐药性的增加,全球发现幽门螺杆菌的治疗效果大幅下降[7]。且其副作用显著,如便秘、腹泻、恶心等不良反应。近年来,益生菌作为一种辅助治疗手段,被广泛研究用于改善铋剂四联疗法的效果及减少其副作用。该文主要从益生菌在幽门螺杆菌感染铋剂四联根除治疗中的作用及其对肠道菌群失调的影响,重点分析了益生菌的疗效、安全性及机制,并探讨了未来研究方向。
文章关键词
幽门螺杆菌;益生菌;治疗;胃肠道微生态
参考文献
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