作者
尹瀚翔,金潇枭,胡佳威,田龍珠,阳春华
文章摘要
铜死亡是近年来发现的一种新的依赖性细胞死亡形式,称为铜依赖性细胞死亡。与细胞凋亡、自噬或焦亡不同,铜死亡的特征是铜可以结合和破坏DNA,结合并激活E2D2诱导的蛋白质泛素化和降解。铜死亡参与多种生理和病理过程,自发现以来,铜死亡越来越多地涉及骨相关疾病。本文重点介绍了铜死亡的最新研究进展和展望,总结了铜死亡的调控机制,讨论了铜死亡在股骨头坏死、骨质疏松症(OP)、骨关节炎(OA)、类风湿性关节炎(RA)和骨肉瘤(OS)等骨相关疾病发病机制中的作用及其治疗潜力。
文章关键词
铜稳态;铜死亡;细胞死亡;骨相关疾病
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