刘瑞丽,迪 吉

本文聚焦胃癌组织中缺氧诱导因子-1α（HIF-1α）蛋白高表达与患者术后生存率的关系。通过整合国内外相关研究，阐述HIF-1α的生物学特性及其在胃癌组织中的表达模式，分析其高表达对术后生存率的影响，并探讨相关作用机制。研究表明，HIF-1α蛋白在胃癌组织中常呈高表达，且与患者术后生存率密切相关，其可能通过调控肿瘤血管生成、细胞增殖与凋亡、侵袭转移等过程影响患者预后。深入研究HIF-1α蛋白有助于为胃癌患者术后治疗及预后评估提供新的理论依据和潜在靶点。

胃癌；HIF-1α蛋白；术后生存率；肿瘤微环境；预后

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