薛 柔,郭 斌,赵春龙

目的：探究代谢相关性疾病和突发性聋的因果关联。方法：从全基因组关联研究汇总数据库中筛选出与代谢相关性疾病（高血压、2型糖尿病、甘油三酯水平和高密度脂蛋白胆固醇水平）强相关的单核苷酸多态性作为工具变量，采用双样本孟德尔随机化（MR）方法分析代谢相关性疾病与突发性聋的因果关联。采用逆方差加权法和MR-Egger法为主要分析方法。使用优势比（OR）及其95%置信区间（CI）作为对暴露与结局间因果关联的评价指标,并采用异质性检验、多效性分析和逐个剔除检验评估MR分析结果的稳健性。结果：IVW法分析结果显示，代谢相关性疾病与突发性聋均无因果效应，分别为HBP：OR=0.47，95%CI：(-1.65,0.15)，P=0.10；T2DM：OR=0.98，95%CI：(-0.12,0.09)，P=0.82；TG：OR=1.03，95%CI：(-0.12,0.19)，P=0.64；HDL-C：OR=0.95，95%CI：(-0.19,0.10)，P=0.55。结论:本研究不支持代谢相关性疾病（高血压、2型糖尿病､甘油三酯水平和高密度脂蛋白胆固醇水平）与突发性聋具有因果效应｡

突发性聋；代谢相关性疾病；孟德尔随机化；因果关联；欧洲

[1] <儿童突发性聋10年住院病例的疗效及预后相关因素分析_陈丹萍.pdf>[J]. [2] WANG X,GAO Y,JIANG R.Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients[J].Front Mol Biosci,2022,9:982561. [3] CHANDRASEKHAR SS,TSAI DO BS,SCHWARTZ SR,et al.Clinical Practice Guideline:Sudden Hearing Loss(Update)Executive Summary[J].Otolaryngol Head Neck Surg,2019,161(2):195-210. [4] KIM YS,TEHRANI ASS,LEE HS.Sudden unilateral hearing loss and vertigo following isolated cerebellar hypoperfusion without infarction due to vertebral artery dissection[J].BMC Neurol,2022,22(1):489. [5] XIONG W,DAI Q,WANG Y,et al.Idiopathic Sudden Sensorineural Hearing Loss in Different Ages:Prognosis of Patients With Initial Total Hearing Loss[J].Front Psychol,2022,13:818967. [6] ZAND V,DADGARNIA M,BARADARANFAR M,et al.The association between metabolic syndrome and the prognosis of idiopathic sudden sensorineural hearing loss[J].Eur Arch Otorhinolaryngol,2023,280(3):1411-5. [7] PARK JS,KIM SH,KIM I,et al.Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss?[J] Life(Basel),2022,12(7). [8] ZHANG J,WU H,WANG R.Metabolic syndrome and esophageal cancer risk:a systematic review and meta‑analysis[J] Diabetol Metab Syndr,2021,13(1):8. [9] LEE H,KONG G,TRAN Q,et al.Relationship Between Ginsenoside Rg3 and Metabolic Syndrome[J] Front Pharmacol,2020,11:130. [10] AJLOUNI K,KHADER Y,ALYOUSFI M,et al.Metabolic syndrome amongst adults in Jordan:prevalence,trend,and its association with socio-demographic characteristics[J] Diabetol Metab Syndr,2020,12(1):100. [11] CHIEN CY,TAI SY,WANG LF,et al.Metabolic Syndrome Increases the Risk of Sudden Sensorineural Hearing Loss in Taiwan:A Case-Control Study[J] Otolaryngol Head Neck Surg,2015,153(1):105-11. [12] LIN J,ZHOU J,XU Y.Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis[J] Brain, 2023,146(8):3364-72. [13] JULIAN TH,BODDY S,ISLAM M,et al.A review of Mendelian randomization in amyotrophic lateral sclerosis[J] Brain,2022, 145(3):832-42. [14] 王惠达,张智,王晗宇,马兴.代谢综合征组成部分与膝关节骨性关节炎的因果关系:孟德尔随机化研究[J] 中国循证医学杂志:1-6. [15] MORRIS DR,JONES GT,HOLMES MV,et al.Genetic Predisposition to Diabetes and Abdominal Aortic Aneurysm:A Two Stage Mendelian Randomisation Study[J] Eur J Vasc Endovasc Surg,2022,63(3):512-9. [16] 尚文茹,魏莉莉,卢存存.受教育程度对系统性红斑狼疮的因果效应:孟德尔随机化研究[J] 华西医学:1-5. [17] TSUZUKI N,WASANO K.Idiopathic sudden sensorineural hearing loss:A review focused on the contribution of vascular pathologies[J] Auris Nasus Larynx,2024,51(4):747-54. [18] SIMOES J,VLAMINCK S,SEICA RMF,ACKE F,MIGUEIS ACE.Cardiovascular Risk and Sudden Sensorineural Hearing Loss:A Systematic Review and Meta-Analysis[J] Laryngoscope,2023,133(1):15-24. [19] ZHANG J,ZHOU L,LIU T,CHENG Y,DOU Y.Cerebral infarction presenting with bilateral sudden deafness as the primary symptom:a case report[J] J Int Med Res,2024,52(12):3000605241305483. [20] CHUNG JH,LEE SH,PARK CW,et al.Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss[J] Laryngoscope,2016,126(8):1918-22. [21] CHEN X,ZHENG Z,LIU X,et al.Traditional and non-traditional lipid parameters as risk factors for sudden sensorineural hearing loss[J] Braz J Otorhinolaryngol,2024,90(4):101435. [22] DENG Y,SHI J,ZHANG M,QI X.Clinical characteristics of cerebral hemorrhage with bilateral sudden deafness as the first symptom[J] Neurol Sci,2021,42(1):141-50. [23] OITICICA J,BITTAR RS.Metabolic disorders prevalence in sudden deafness[J] Clinics(Sao Paulo),2010,65(11):1149-553. [24] WANG H,ZHAO Z,CHEN S.Local vs Systemic Use of Steroids for Sudden Deafness with Diabetes:A Systematic Review and Meta- Analysis[J] Ear Nose Throat J,2023:1455613231170090. [25] FAZIA T,BALDRIGHI GN,NOVA A,BERNARDINELLI L.A systematic review of Mendelian randomization studies on multiple sclerosis[J] European Journal of Neuroscience,2023,58(4):3172-94. [26] MA C,ZHANG W,MAO L,et al.Hyperhomocysteinemia and intracranial aneurysm:A mendelian randomization study[J] Front Neurol, 2022,13:948989.

点击下载PDF