多囊卵巢综合征（PCOS）是一种常见的妇科内分泌代谢紊乱疾病，影响全球大量育龄女性。近年来，细胞焦亡作为一种新型程序性坏死，在PCOS发病机制中的作用逐渐受到关注。本综述系统总结了细胞焦亡的分子机制，深入探讨其在PCOS卵巢颗粒细胞、脂肪细胞及其他相关细胞中的变化，分析细胞焦亡与PCOS代谢紊乱、炎症反应和氧化应激的关联，同时阐述目前针对细胞焦亡治疗PCOS的潜在策略，为PCOS的发病机制研究和治疗提供新的思路与方向。

[1] TEEDE H J,TAY C T,LAVEN J J E,et al.RecommendationsFrom the 2023 international evidence-based guideline for the as-sessment and management of polycystic ovary syndrome[J].JClin Endocrinol Metab,2023,108(10):2447-69.
[2] ATABAKI R,KHALEGHZADEH-AHANGAR H,ESMAEILI N,et al.Role of pyroptosis,a pro-inflammatory programmed cell death,in epilepsy[J].Cell Mol Neurobiol,2023,43(3):1049-1059.
[3] 陈讯,陈雯昕,张文,等.基于焦亡相关基因构建多囊卵巢综合征诊断模型[J].南京医科大学学报(自然科学版),2025,45(04):509-522.
[4] Peng Y,Yang Y,Li Y,et al.Mitochondrial(mt)DNA-cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling promotes pyroptosis of macrophages via interferon regulatory factor(IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis[J].Cell Mol Biol Lett,2024,29:61.
[5] Shi J,Zhao Y,Wang Y,et al.Inflammatory caspases are innate immune receptors for intracellular LPS.Nature,2014,514:187-192.
[6] 项雨,丁慧敏,陈田,等.高雄激素通过诱导细胞焦亡影响卵巢颗粒细胞增殖[J].生殖医学杂志,2023,32(09):1399-1406.
[7] 孙文萍,赵得雄,王榀华,等.TXNIP/NLRP3信号通路在PCOS-IR大鼠卵巢慢性炎症中的作用机制研究[J].中国免疫学杂志, 2022,38(11):1300-1305.
[8] AZZIZ R,CARMINA E,CHEN Z,et al.Polycystic ovary syndrome[J].Nat Rev Dis Primers,2016,2:16057.
[9] LEGRO R S,ARSLANIAN S A,EHRMANN D A,et al.Diagnosis and treatment of polycystic ovary syndrome:an Endocrine Society clinical practice guideline[J].J Clin Endocrinol Metab,2013,98(12):4565-92.
[10] HU W,XIE N,ZHU H,et al.The effective compounds and mechanisms of Cang-Fu-Dao-Tan Formula in treating polycystic ovary syndrome based on UPLC/Q-TOF-MS/MS,network pharmacology and molecular experiments[J].J Pharm Biomed Anal,2024,239:115867.
[11] Chinese guideline for diagnosis and management of polycystic ovary syndrome][J].Zhonghua Fu Chan Ke Za Zhi,2018,53(1):2-6.