钟 斐,谢单宁,吴 娟,陈雅琪,李 娟

痛风是一种单钠尿酸盐沉积所致的晶体相关性关节病，部分痛风患者会进展至慢性痛风石病变期，此阶段以皮下痛风石结节形成、持续性关节炎症以及潜在的骨侵蚀为特征，进而可能引发关节畸形和功能障碍。本文综述了当前常用的痛风骨侵蚀动物模型构建方法，主要包括在啮齿类动物（如大鼠、小鼠）关节腔内直接注射MSU晶体或尿酸氧化酶抑制剂（如氧嗪酸钾）诱导高尿酸血症及局部晶体注射刺激。以期为痛风骨侵蚀相关研究提供参考。

痛风；骨侵蚀；动物模型

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