高敬琼,张庆欣

阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）是一种常见的睡眠障碍，其通过间歇性低氧、睡眠结构片段化等机制损害脑类淋巴系统功能，导致β-淀粉样蛋白等神经毒性物质清除障碍，进而增加认知损伤与神经退行性疾病风险。近年来，多模态磁共振成像技术为无创评估类淋巴功能提供了新途径：DTI-ALPS指数可量化类淋巴引流效率，其降低与OSA严重程度显著相关；扩散峰度成像（DKI）能更敏感地探测白质微结构异常，揭示与认知功能障碍相关的早期损伤；静息态功能磁共振则通过脑脊液-血氧耦合分析提供功能视角。

类淋巴系统（GS）；阻塞性睡眠呼吸暂停；磁共振成像；脑结构和功能；综述

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