孙 静,韩彦渊,张 曼

2型糖尿病（T2DM）作为一种常见的慢性代谢性疾病，全球范围患病率持续增长，需要早期识别和干预。研究表明，40%的糖尿病患者在诊断前5年左右仍表现为糖耐量正常（NGT），且在部分NGT人群中存在葡萄糖耐量实验（OGTT）1小时血糖（1h-PG）升高的现象，提示现行的糖尿病前期诊断标准（如空腹血糖受损（IFG）、糖耐量受损（IGT）和糖化血红蛋白（HbA1c））可能无法完全覆盖所有高危人群。国内外一些研究显示，1h-PG与空腹血糖（FPG）和OGTT2小时血糖（2h-PG）相比，1h-PG能更早识别糖尿病前期，并对心血管疾病、代谢综合征及微血管并发症具有更高的预测价值。目前，关于1h-PG筛查的正常值范围与最佳切点尚无统一标准，尤其缺乏中国人群的大规模数据。未来需进一步深入研究其机制，确立适用于中国人群的切点值，为T2DM的早期防控提供新策略。

糖尿病前期；葡萄糖耐量实验试1hPG；胰岛素抵抗；胰岛β细胞功能

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