王志高,李 婷,蒋 龙

目的：本研究旨在探讨中性粒细胞明胶酶相关载脂蛋白（NGAL）联合急性肾损伤危险预测评分（RISKS）对脓毒症相关急性肾损伤的预测价值。方法：我们选取了2022年7月至2024年5月在本院收治的185例脓毒症患者，依据急性肾损伤的情况将其分为急性肾损伤组（55例）和非急性肾损伤组（130例）。收集并分析两组患者的性别、年龄、基础疾病情况、肾毒性暴露、机械通气、首个24小时尿量、白细胞计数（WBC）、血红蛋白（HB）、降钙素原（PCT）、pH值、APACHEⅡ评分、SOFA评分等相关指标，并计算RISKS评分。采用单因素与多因素Logistic回归分析脓毒症并发急性肾损伤的影响因素。结果：急性肾损伤组患者的NGAL水平、APACHEⅡ评分、SOFA评分及RISKS评分均显著高于非急性肾损伤组（均P<0.05）。Logistic回归分析显示，NGAL与RISKS评分是脓毒症相关急性肾损伤的独立危险因素。ROC曲线分析表明，NGAL与RISKS评分联合诊断的曲线下面积（AUC）高于单项指标，联合诊断效果更佳。结论：NGAL及RISKS评分的联合应用在脓毒症相关急性肾损伤的早期预测中具有较高的临床价值，能够有效提高对急性肾损伤的早期识别率和诊断准确性。

NGAL；RISKS评分；脓毒症；急性肾损伤；预测价值

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