高竟航,李文辉

经鼻蝶入路手术是垂体腺瘤的首选治疗方式，但术后垂体功能减退作为常见并发症，严重影响患者生活质量甚至增加病死率，已成为临床关注的重点[1]。本文综述经鼻蝶入路垂体腺瘤术后垂体功能减退的研究进展，从发病机制、危险因素、诊断方法及治疗管理等方面展开阐述，分析手术创伤、血供障碍等发病相关因素，梳理肿瘤特性、手术方式等危险因素，总结内分泌学检查等诊断手段及激素替代治疗等干预措施，并对未来生物标志物研发、手术技术优化等研究方向进行展望，为临床诊疗及研究提供参考。

经鼻蝶入路；垂体腺瘤；术后并发症；垂体功能减退；激素替代治疗

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