陈鸿镇,袁 霞

强直性脊柱炎（Ankylosing Spondylitis，AS）是一种炎症性疾病，以骶髂关节和脊柱炎症为特征，晚期可导致骨性融合。其病因是遗传背景和环境因素复杂相互作用的结果。虽然在过去的几十年里取得了重大进展，但AS的病因机制在一定程度上仍不清楚。迄今为止，研究已经揭示了一些可能与AS发生有关的因素，包括遗传背景、免疫反应、微生物因素、代谢异常等。基于此，该文总结AS潜在的发病机制，以期为AS的治疗提供参考。

强直性脊柱炎；作用机制；HLA-B27；炎性反应；机械应力；肠道菌群

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