鄢雨萌,张智慧,祁冰雪,芦小单,丁亦男

近年来，肥胖已经成为全球重大公共卫生问题。肥胖显著增加2型糖尿病、心血管疾病等慢性疾病的发病风险，给医疗体系带来了巨大的经济压力。从糖脂能量代谢视角，梳理了肥胖发病的关键分子信号通路，肥胖通过中枢-外周“失耦合”形成“高摄入－低消耗－激素抵抗－炎症－脂质沉积”恶性循环，导致胰岛素抵抗和2型糖尿病。深入阐明肥胖发病的分子信号网络，以期为开发新型防治策略提供理论依据，突破当前肥胖治疗的瓶颈。

肥胖；能量代谢；糖代谢；脂代谢

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