张翔珂,董雨萌,陈 铭,张新宇,阎雪莹

随着纳米材料研究的深入，纳米药物输送系统在癌症的治疗与诊断方面的应用越来越广泛。其中，介孔二氧化硅纳米颗粒（MSN）具有比表面积大、孔体积大、孔径可调、生物相容性高等独特优势，有利于在其基础上合成多功能的抗肿瘤药物。合成的功能化MSN的递送系统可以显著提高癌症的治疗效果并减少对正常组织的细胞毒性。为了进一步改善MSN的体内特性和潜在的临床转化，设计具有适当结构和理想的靶向效果的MSN至关重要。在这篇综述中，我们讨论了影响MSN合成以及载药的因素，重点总结了基于功能化MSN的癌症治疗系统的新研究进展。此外，就功能化MSN用于癌症治疗的挑战与未来展开了讨论。

介孔二氧化硅纳米粒；功能化修饰；药物；靶向性修饰；刺激响应性修饰

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