李阳光,吴 帆

甲磺酸盐及紫外线敏感性81号基因（methyl methanesulfonate and UV sensitive gene clone 81，Mus81）是定位于人11号染色体长臂的DNA修复基因，与多种恶性肿瘤的发生发展密切相关。目前Mus81在多种癌症组织呈现低表达，影响肿瘤细胞的增殖、侵袭、迁移及凋亡等方面，是肿瘤发生发展的抑制因子。Mus81对肿瘤的分子调控作用，提示其可成为肿瘤治疗的新靶点。本文就Mus81的分子结构与生理功能及其与各种肿瘤的关系作一综述，以期为临床治疗提供参考。

Mus81基因；恶性肿瘤；分子调控机制

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