Car-T疗法在肿瘤治疗中的应用与当前的困境

ISSN:2811-051X(P)

EISSN:2811-0781(O)

语言:中文

作者
陈志荣
文章摘要
免疫治疗作为当下治疗肿瘤的一种极为有效的手段受到了全世界的广泛关注。Car-T治疗则是目前免疫治疗中很有前景的一种方式,目前已经在血液瘤的治疗中得到了很好的应用,并且取得了不小的成果。但Car-T治疗在实体瘤的治疗过程中却受到了肿瘤微环境和肿瘤异质性等影响,治疗效果有限。如何增强Car-T细胞对实体瘤的浸润效果成了目前研究人员最为关注的一个问题。
文章关键词
肿瘤;免疫治疗;Car-T;肿瘤微环境
参考文献
[1]Javad Masoumi,Abdollah Jafarzadeh,Jalal Abdolalizadeh,Haroon Khan,Jeandet Philippe,Hamed Mirzaci,Hamid Reza Mirzaei.Cancer stem cell-targeted chimeric antigen receptor(Car)-T cell therapy:Challenges and prospects[J].Acta Pharnaceutica Sinica B,2021,11(07):1721-1739. [2]徐广贤.Car-T细胞免疫疗法在肿瘤治疗中的研究进展[J].广东医科大学学报,2022,40(02):121-131. [3]Chong,Elise A. and Ruella,Marco and Schuster,Stephen J.Five-Year Outcomes for RefractoryB-Cell Lymphomas with Car T-Cell Therapy[J].New England Journal ofMedicine,2021,384(7) [4]赵莹莹,王咪咪,崔杰峰.微环境参与消化系统肿瘤放化疗抵抗机制新进[J].世界华人消化杂志,2022,30(08):341-348. [5]黄波.肿瘤微环境中免疫与炎症的调节[J].中国肿瘤生物治疗杂志,2012,19(02):111-115. [6]霍宏宇,胡苏琼,孙洋,阮江飞,孙志洋,廖国阳,余敏.肿瘤微环境及其能量代谢的重编程[J].生命科学,2017,29(01):70-76.DOI:10.13376/j.cbls/2017010. [7]Jessica Wagner,Elizabeth Wickman,Christopher DeRenzo,Stephen Gottschalk.Car T CellTherapy for Solid Tumors: Bright Future or Dark Reality?[J]MolecularTherapy.2020,28(11):2320-2339. [8]Feifei Guo, Jiuwei Cui.Car-T in solid tumors: Blazing a new trail through thebrambles[J]Life Sciences.2020,260:118300. [9]Lionel A. Kankeu Fonkoua, Olivia Sirpilla, Reona Sakemura, Elizabeth L. Siegler, Saad S.Kenderian.Car T cell therapy and the tumor microenvironment: Current challenges andopportunities.[J]Molecular Therapy-Oncolytics.2022,25:69-77. [10]姚铮,李子涵,高利明,胡星,陈颜,潘文琦,李谦.Car-T细胞免疫治疗实体瘤的研究进展[J].中国药科大学学报,2021,52(04):496-504. [11] Watanabe,N.,Bajgain,P, Sukumaran, S., Ansari, S., Heslop, H.E., Rooney, C.M.,Brenner, M.K., Leen,A.M., and Vera, J.F.(2016). Fine-tuning the CAR spacer improves T-cellpotency.Oncolmmunology 5,e1253656.
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