阿不都克里木·阿不都,孙惠萍

脓毒血症是当今急危重症中常见的感染性疾病，伴有心功能障碍的脓毒血症患者有着较高的病死率。由脓毒血症引起的心功能障碍被称为脓毒性心肌病，线粒体障碍是其主要发病机制之一，但仍有诸多问题尚不明确，本文阐述了关于脓毒性心肌病线粒体障碍的最新研究进展及其潜在治疗方案，为脓毒性心肌病的治疗提供参考依据。

脓毒症；脓毒症心肌病；心力衰竭；线粒体障碍

[1]Zanotti-Cavazzoni,S.L.and S.M.Hollenberg,Cardiac dysfunction in severe sepsis and septic shock.Curr Opin Crit Care,2009.15(5):p.392-7. [2]Friedman,J.R.and J.Nunnari,Mitochondrial form and function.Nature,2014.505(7483):p.335-43. [3]Li,Y.,et al.,Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis.Redox Biol,2021.38:p.101771. [4]Jiang,X.,et al.,Irisin Attenuates Oxidative Stress,Mitochondrial Dysfunction,and Apoptosis in the H9C2 Cellular Model of Septic Cardiomyopathy through Augmenting Fundc1-Dependent Mitophagy.Oxid Med Cell Longev,2021.2021:p.2989974. [5]Chen,M.,et al.,LncRNA SOX2OT Mediates Mitochondrial Dysfunction in Septic Cardiomyopathy.DNA Cell Biol,2019.38(11):p.1197-1206. [6]Liang,D.,et al.,Down-regulation of Xist and Mir-7a-5p improves LPS-induced myocardial injury.Int J Med Sci,2020.17(16):p.2570-2577.

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