刘盼盼,杨 佳

多发性硬化（MS）是一种慢性炎性脱髓鞘疾病，而认知障碍是MS患者在临床上最常见的非运动症状。早期的常规磁共振成像（MRI）可以显示明显的脱髓鞘病灶，大脑网络的广泛变化会导致认知功能障碍，但是常规核磁可见的白质异常程度并不能完全解释多发性硬化症患者认知障碍的严重程度。多种MRI技术能够评估大脑中微结构损伤，对于早期发现MS患者认知功能障碍，并对认知障碍进行干预有重要意义。本文对MS患者的认知功能磁共振成像研究展开综述。

多发性硬化；认知功能；脑萎缩；磁共振成像

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