罗世振

目的：分析不同用药方案治疗胃溃疡伴胃出血的应用价值。方法：选取2021年1月-2023年10月100例胃溃疡伴胃出血患者，随机分组。对照组采用奥美拉唑+铝碳酸镁的治疗方案，观察组则加入瑞巴派特。比较两组各指标差异。结果：①疗效相比，观察组更高，差异有意义（P＜0.05）；②不良反应相比，两组差异无意义（P＞0.05）；③症状缓解时间相比，观察组更短，差异有意义（P＜0.05）；④血清炎症因子变化幅度相比，观察组更高，差异有意义（P＜0.05）。结论：瑞巴派特联合奥美拉唑+铝碳酸镁的疗效与安全性高，可快速缓解呕血、便血、腹痛、腹胀等症状，减轻炎症反应，可推广使用。

瑞巴派特；胃溃疡；胃出血

[1] 黄艳丽,雷建富.奥美拉唑联合铝碳酸镁对胃溃疡伴胃出血患者临床疗效及免疫功能的影响[J].天津药学,2023,35(5):60-63. [2] 程显星.铝碳酸镁联合奥美拉唑、山莨菪碱治疗老年慢性萎缩性胃炎的效果及对胃肠功能的影响[J].临床合理用药,2023,16(11):90-93. [3] MARZIYE,FARSIMADAN,FATEMAH SADEGHPOUR,HERAVI,ALIREZA,EMAMVIRDIZADEH,et al.Evaluation of Helicobacter pylori Genotypes in Obese Patients with Gastric Ulcer,Duodenal Ulcer,and Gastric Cancer:An Observational Study[J].Digestive diseases,2022,40(3):355-361. [4] BEIRANVAND,MOHAMMAD,BAHRAMIKIA,SEIFOLLAH,DEZFOULIAN,OMID.Evaluation of antioxidant and anti-ulcerogenic effects of Eremurus persicus(Jaub&Spach)Boiss leaf hydroalcoholic extract on ethanol-induced gastric ulcer in rats[J].Inflammopharmacology,2021,29(5):1503-1518. [5] 韩芳,张利娟,杜勇.奥美拉唑四联疗法联合瑞巴派特对幽门螺杆菌阳性胃溃疡患者胃肠激素水平、溃疡愈合情况及幽门螺杆菌根除率的影响[J].临床内科杂志,2023,40(5):346-347. [6] 王晓辉,罗哲,刘新尧,等.瑞巴派特在 Hp 阳性胃溃疡患者治疗中的临床疗效分析[J].中华航海医学与高气压医学杂志,2023,30(1):72-75. [7] ABDEL-KAWI,SAMRAA HUSSEIN,HASHEM,KHALID SHAABAN,SAAD,MARINA KAMEL,et al.The ameliorative effects of cinnamon oil against ethanol-induced gastric ulcer in rats by regulating oxidative stress and promoting angiogenesis[J].Journal of molecular histology,2022,53(3):573-587. [8] SEHITOGLU,MUSERREF HILAL,OZTOPUZ,OZLEM,KARABOGA,IHSAN,et al.Humic Acid Has Protective Effect on Gastric Ulcer by Alleviating Inflammation in Rats[J].Cytology and genetics,2022,56(1):84-97. [9] 代玉霞,王转转.艾司奥美拉唑联合铝碳酸镁对胃溃疡伴出血患者免疫功能及溃疡愈合的影响[J].反射疗法与康复医学,2023,4(3):116-119. [10] 郑艺.艾司奥美拉唑联合铝碳酸镁对胃溃疡患者的疗效及黏膜愈合质量的影响[J].基层医学论坛,2023,27(32):148-150. [11] HIROMITSU BAN,OSAMU INATOMI,MASAKI MURATA,et al.Vonoprazan vs lansoprazole for the treatment of artificial gastric ulcer after endoscopic submucosal dissection:a prospective randomized comparative study[J].Journal of clinical biochemistry and nutrition.,2021,68(3):259-263. [12] SALLAM,AL-ALIAA M.,DARWISH,SAMAR F.,EL-DAKROURY,WALAA A.,et al.Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats:Insights on MAPK and Nrf2/HO-1 signaling pathway[J].Pharmaceutical research,2021,38(11):1821-1838. [13] 池芳芳.瑞巴派特联合艾司奥美拉唑和康复新液对胃溃疡出血患者的临床疗效[J].中外医学研究,2023,21(6):105-108. [14] 孙林林.艾司奥美拉唑联合瑞巴派特对胃溃疡伴胃出血患者炎症反应及溃疡愈合的影响[J].反射疗法与康复医学,2023,4(7):128-131. [15] HUSSEIN,JIHAN,EL-BANA,MONA A.,EL-NAGGAR,MEHREZ E.,et al.Prophylactic effect of probiotics fortified with Aloe vera pulp nanoemulsion against ethanol-induced gastric ulcer[J].Toxicology mechanisms and methods,2021,31(1/9):699-710. [16] COLLATUZZO,GIULIA,ALICANDRO,GIANFRANCO,BERTUCCIO,PAOLA,et al.Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status,tobacco smoking,alcohol drinking and salt intake[J].Journal of epidemiology and community health,2022,76(10):861-866. [17] 王娜.瑞巴派特联合奥美拉唑和生长抑素治疗胃溃疡出血患者的效果[J].中国民康医学,2022,34(6):26-28. [18] 袁浩钧,彭娇娇.艾司奥美拉唑联合瑞巴派特治疗消化性胃溃疡患者的临床疗效[J].临床合理用药杂志,2022,15(9):105-108. [19] 王婉真,蔡梁椿.雷贝拉唑联合瑞巴派特治疗活动性胃溃疡疗效及对炎性反应的影响[J].临床合理用药杂志,2021,14(19):88-90. [20] 郭洪礼,张涛,梁红亮.瑞巴派特改良四联疗法用于幽门螺旋杆菌阳性胃溃疡的临床观察[J].中国药房,2021,32(12):1497-1500.

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