薛宾阁,李 静,高 宏,孟双双

血小板减少症是一种比较常见的血液疾病，其病因复杂，涉及多种因素，包括免疫性疾病、感染、药物反应以及营养缺乏等。近年来，微量元素在血小板生成和功能中的作用越来越受到关注，尤其是在血小板减少的病理生理过程中。微量元素如锌、硒和铜等在多项生物合成过程中发挥重要作用，缺乏这些元素可能导致血小板生成障碍及其功能异常。本文旨在系统评估微量元素缺乏与血小板减少之间的关系，探讨其潜在机制及临床影响。通过分析相关研究，我们将阐明微量元素在血小板生理中的重要性，并讨论其缺乏对血小板生成的影响，为临床诊断和治疗提供新的思路。该综述不仅为理解血小板减少的复杂机制提供了新的视角，也为临床实践中微量元素的监测及补充治疗提供了理论依据。

血小板减少，微量元素，缺乏，机制，临床影响

[1] Hidiatov O,Zlamal J,Aidery P,Bakchoul T.[Acquired immune thrombocytopenia:An update on aspects of diagnosis and management relevant for intensive care medicine].Dtsch Med Wochenschr.2020;145(11):747-753. [2] Taiorazova G,Alimbaeva A,Tanatarov S.The role of vitamin D and trace elements in premature newborns with congenital pneumonia. Bratisl Lek Listy.2023;124(8):572-577. [3] Sincan G,Erdem F,Bayİ,Sincan S.Serum Copper and Zinc Levels in Primary Immune Thrombocytopenia.Biol Trace Elem Res.2022; 200(9):3919-3924. [4] Nevzorova TA,Mordakhanova ER,Daminova AG,et al.Platelet factor 4-containing immune complexes induce platelet activation followed by calpain-dependent platelet death.Cell Death Discov.5:106.Published 2019. [5] Raghunathan S,Rayes J,Sen Gupta A.Platelet-inspired nanomedicine in hemostasis thrombosis and thromboinflammation.J Thromb Haemost.2022;20(7):1535-1549. [6] Meng P,Liu W,Lao J,et al.Paclitaxel improves thrombopoiesis in the absence of thrombopoietin receptor(Mpl).J Thromb Haemost. 2024;22(12):3599-3613. [7] Yan C,Wu H,Fang X,He J,Zhu F.Platelet,a key regulator of innate and adaptive immunity.Front Med(Lausanne).10:1074878.Published 2023. [8] Kerris EWJ,Hoptay C,Calderon T,Freishtat RJ.Platelets and platelet extracellular vesicles in hemostasis and sepsis.J Investig Med. 2020;68(4):813-820. [9] Golara A,Kozłowski M,Guzik P,Kwiatkowski S,Cymbaluk-Płoska A.The Role of Selenium and Manganese in the Formation,Diagnosis and Treatment of Cervical,Endometrial and Ovarian Cancer.Int J Mol Sci.2023;24(13).Published 2023 Jun 29.

点击下载PDF